Estrofem is commonly prescribed for: Hormone Replacement Therapy (HRT), especially for: Menopausal or post-menopausal women Transgender women as part of feminizing hormone therapy Relief of menopause symptoms such as: Hot flashes Night sweats Vaginal dryness Prevention of bone loss (osteoporosis) in some patients What type of hormone it is Estradiol = a bioidentical estrogen (similar to estrogen naturally produced by the body) Usually taken as an oral tablet, but estrogen also exists in patches, gels, or injections (different brands)